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Showing posts with the label genomics

✨🧬 Useful Clustering Algorithms for Bioinformaticians! 🧬✨

🧠 In the realm of Bioinformatics data comes in myriad forms. Clustering algorithms sift through mountains of data points, grouping them into meaningful categories based on similarities, ultimately shedding light on biological relationships, structures, and functions.  Here are some clustering algorithms you should know about (and use cases too! 😎): 1️⃣ CD-HIT (Cluster Database at High Identity with Tolerance): 📚 How it works: CD-HIT clusters similar biological sequences based on sequence  identity, with an adjustable threshold.   💡 Use Case: Clustering protein or nucleotide sequences to reduce redundancy and accelerate sequence searches in databases like UniProt or GenBank. 2️⃣ K-Means Clustering:   📚 K-Means partitions data into 'k' clusters by iteratively assigning each data point to the nearest cluster centroid and updating centroids based on the mean of data points in each cluster.   💡 Use Case: Segmenting gene expression data to identify distinct groups of genes with

The Marvel of Molecular Biology: DNA Replication, Transcription, and Translation

  The Marvel of Molecular Biology The Central Dogma of Life,   a fundamental concept in molecular biology, describes the flow of genetic information within a biological system. It was first proposed by Francis Crick in 1958 and further expanded upon in 1970.  The Central Dogma involves three key processes: DNA replication, transcription, and translation DNA Replication DNA replication is the process by which a cell duplicates its DNA before cell division, ensuring that each new cell receives an exact copy of the genetic instructions. The replication process begins at specific locations on the DNA molecule called origins of replication, where the double helix unwinds to expose the template strands.  Each strand of the DNA molecule serves as a template for the synthesis of a new complementary strand, following the base pairing rules (A pairs with T, and G pairs with C).  The result is two identical DNA molecules, each composed of one original strand and one newly synthesized strand . Tra